I already have my pick for 21...though there was unfortunately a legion of candidates. I decided to go with a character getting screwed over by canon in a more meta way, as opposed to what happens to them in the show. And no, I'm not giving any more clues until then. :P

I don't even know why I watch SPN. "Dreary soap opera" is a hilarious description though-they sure do cry a lot.

Haven't seen House yet (and now I want to).